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- Ketones serve as an alternative energy source for the brain, substituting sugar.
- Researchers are investigating the potential of ketone ester beverages to enhance human lifespan.
- However, consuming ketones does not replicate the effects of a ketogenic diet.
While it may not be a miraculous elixir for eternal youth, it could represent a small step in that direction.
A team at the Buck Institute for Research on Aging in Northern California is gearing up to explore whether a tropical-flavored shot taken twice daily can extend human longevity. The hypothesis suggests that older adults who consume ketone esters—supplements aimed at enabling the body to utilize ketones instead of sugar—might experience increased vitality and energy levels.
Ketones have gained popularity among biohackers in Silicon Valley, who regard them as the body’s “preferred” fuel source during fasting or when glucose levels are insufficient to support bodily functions effectively.
“In reality, they act as an essential backup,” explained Brianna Stubbs, director of translational science at the Buck Institute, during an interview with Business Insider.
The body typically resorts to burning ketones when carbohydrate availability is low. “Whenever there are ketones present in the bloodstream, they become the primary energy source over sugar,” she added.
This state is referred to as “ketosis,” where cells derive their energy from ketones rather than glucose. Ketosis evolved as a protective mechanism against damage during food shortages. Researchers believe this natural metabolic switch could be leveraged for healthier aging since various organs—including the brain—become less adept at utilizing sugar efficiently with age.
The nationwide study led by Stubbs and her mentor Dr. John Newman will assess whether older individuals consuming these shots exhibit reduced frailty and improved metrics such as walking ability or enhancements in mood and cognitive function.
Ketone Beverages vs. Ketogenic Diets: Understanding Key Differences
Juvenescence
Both fasting and low-carbohydrate high-fat diets like keto can elevate blood ketone levels; however, they achieve this through different mechanisms compared to drinking ketone esters. Unlike fasting or ketogenic diets that require fat conversion into ketones by the liver, these drinks deliver ready-made ketones directly into circulation via digestion in both stomach and liver tissues.
“If weight loss is your goal, you should aim to burn your own fat while converting it into usable energy,” Stubbs noted. Ketone drinks do not facilitate this process; thus they shouldn’t be viewed as shortcuts.”
For years scientists speculated about using these beverages for athletic performance enhancement prior to competitions—a notion even supported by investments from military research initiatives. However recent insights suggest that athletes might benefit more from using them post-exercise for recovery purposes instead.
Stubbs herself utilized them after completing an intense six-day ultramarathon covering 380 kilometers across rugged Welsh terrain; she consumed both carbohydrates/proteins alongside her shots during breaks aiming towards optimal recovery post strenuous activity while preserving muscle mass and overall vitality.
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Seniors often face challenges utilizing sugars effectively; hence there’s optimism surrounding how these ester supplements might assist their bodies’ strength maintenance while potentially alleviating inflammation issues along with enhancing mood/cognitive capabilities—but further research remains necessary before drawing conclusions on efficacy here too!
An independent expert specializing in fasting & ketosis Mark Mattson (former head National Institute Aging’s neuroscience lab) expressed enthusiasm regarding upcoming trials stating: “This study holds promise worth exploring.” He emphasized its safety profile adding he looks forward particularly observing impacts upon aging brains which tend toward cognitive decline risks including conditions like Parkinson’s disease.
Nonetheless he cautioned against overlooking benefits derived from achieving ketosis through methods such intermittent fasting which offer additional advantages beyond mere consumption alone!
A preliminary pilot trial conducted recently indicated safety amongst participants aged 65+ over four months testing period where common side effects included nausea/upset stomachs typical within any form induced state regardless if achieved via dietary restrictions/fasting protocols alike!
The larger-scale trial set forth involves 180 seniors across California Connecticut Ohio lasting five months focusing specifically assessing potential improvements related frailty recruitment begins November!
The objective behind recruiting individuals likely experiencing gradual declines physically described themselves slowing down reflects real-life challenges faced today perhaps even simple tasks like walking two blocks becoming increasingly daunting than before! Results anticipated won’t emerge until around 2028 according Stubbs’ projections assuming favorable outcomes arise eventually envisioning scenarios wherein elderly individuals grappling muscle loss/cognitive deterioration could incorporate regular doses morning/evening routines but stresses personalized recommendations tailored individual needs remain crucial rather than one-size-fits-all solutions being applied universally!
If I had my super fit healthy ninety-year-old taking only one statin without other complications functioning optimally I’d advise caution suggesting adding unnecessary elements unless truly warranted,” concluded Stubb’s remarks emphasizing importance individualized approaches moving forward!”
